Substituted indole compounds having NOS inhibitory activity

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

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C544S143000, C546S112000, C546S135000, C546S201000, C546S277400, C548S312100, C548S466000, C548S467000, C548S503000, C514S217080, C514S235200, C514S299000, C514S305000, C514S323000, C514S339000, C514S414000

Reexamination Certificate

active

11404267

ABSTRACT:
The present invention features inhibitors of nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing conditions such as, for example, stroke, reperfusion injury, neurodegeneration, head trauma, CABG, migraine headache with and without aura, migraine with allodynia, central post-stroke pain (CPSP), neuropathic pain, morphine/opioid induced tolerance and hyperalgesia.

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