Substituted indole acid derivatives as inhibitors of...

Details Substituted indole acid derivatives as inhibitors of... Substituted indole acid derivatives as inhibitors of...

2006-07-11

2006-07-11

Stockton, Laura L. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S493000, C548S494000

Reexamination Certificate

active

07074817

ABSTRACT:
This invention provides compounds of the formula:wherein: X is a chemical bond, —CH2— or —C(O)—; R1is alkyl, cycloalkyl, —CH2-cycloalkyl, pyridinyl, —CH2-pyridinyl, phenyl or benzyl; R2is H, alkyl, cycloalkyl, —CH2-cycloalkyl, or perfluoroalkyl; R3is H, halo, alkyl, perfluoroalkyl, alkoxy, cycloalkyl, —CH2-cycloalkyl, —NH2, or —NO2; R4is optionally substituted phenyl, benzyl, benzyloxy, pyridinyl, or —CH2-pyridinyl, or the salt or ester forms thereof, as well as methods for using the compounds as inhibitors of plasminogen activator inhibitor-1 (PAI-1) and as therapeutic compositions for treating conditions resulting from fibrinolytic disorders such as deep vein thrombosis and coronary heart disease, and pulmonary fibrosis.

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