Substituted imidazolylmethyl pyridine and pyrazine...

Details Substituted imidazolylmethyl pyridine and pyrazine... Substituted imidazolylmethyl pyridine and pyrazine...

2006-01-03

2006-01-03

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S333000, C514S341000, C544S295000, C544S405000, C546S256000, C546S272700

Reexamination Certificate

active

06982268

ABSTRACT:
Substituted imidazolylmethyl pyridine and pyrazine derivatives that bind to GABAAreceptors are provided. Such compounds may be used to modulate ligand binding to GABAAreceptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAAreceptors (e.g., receptor localization studies).

REFERENCES:
patent: 5017591 (1991-05-01), Matthews et al.
patent: 5147863 (1992-09-01), Matthews et al.
patent: 6127395 (2000-10-01), DeSimone et al.
patent: 6552037 (2003-04-01), Cai et al.
patent: 2003/0069257 (2003-04-01), Li et al.
patent: 26 51 580 (1978-06-01), None
patent: 2 054 567 (1991-02-01), None
patent: WO 01/12604 (2001-02-01), None
patent: WO 02/50062 (2002-06-01), None
patent: WO 03/033486 (2003-04-01), None
Hawley's Condensed Chemical Dictionary, 12th ed., Richard J. Lewis, Sr. , © 1993 by Van Nostrand Reinhold. p. 594.
Concise Encyclopedia Chemistry, edited by Drs. Hans-Dieter Jakubke and Hans Jeschkeit, © 1993 by Walter de Gruyter & Co p. 490.
McGraw-Hill Dictionary of Chemical Terms, 3rd ed. edited by Sybil P. Parker, © 1984 McGraw-Hill, Inc., p. 200.
Murray, “Pyschosomatic Aspects of Gout” The Journal of General Psychology, vol. 103, pp. 131-138 (1980).
Chesson et al, “Gout: nursing and medical actions” Nursing Standard, vol. 5(13,14), pp. 30-32 (Dec. 19, 1990).
American Radiolabeled Chemicalscatalog No. ARC-1127.
Cooper et al., (1991)The Biochem. Basis of Neuropharm. 6thEdition pp. 145-148.
Kuhnz (1998)Drug Metabolism and Disposition26:1120-1127.
Mohler et al., (1995)Neuroch. Res.20(5):631-636.
Oravcova, et al., (1996)Journal of Chromatography B677:1-27.
White, et al. (1995)Neuro Report6:1313-1316.
White, et al. (1995)Receptor and Channels3:1-5.

Affiliated with

Also associated with

Rating

Substituted imidazolylmethyl pyridine and pyrazine... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted imidazolylmethyl pyridine and pyrazine..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted imidazolylmethyl pyridine and pyrazine... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3542964