Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-04-17
1999-10-12
Fan, Jane
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5462741, C07D40104, A61K 3144
Patent
active
059655836
ABSTRACT:
This invention relates to a series of substituted imidazoles of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention inhibit the production of a number of inflammatory cytokines, and are useful in the treatment of diseases associated with overproduction of inflammatory cytokines.
REFERENCES:
patent: 4503065 (1985-03-01), Wilkerson
patent: 4608382 (1986-08-01), Ferrini et al.
patent: 5633377 (1997-05-01), Thurkauf et al.
Beers Scott A.
Malloy Elizabeth A.
Wachter Michael P.
Wu Wei
Fan Jane
Harbour John
Ortho-McNeil Pharmaceutical , Inc.
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