Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhi

Details Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhi Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhi

1984-06-20

1986-10-14

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546121, A61K 3144, C07D47104

Patent

active

046173072

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1 represents cyano, nitro or C.sub.1 -C.sub.4 -alkyl or the 7,8-dihydro derivative thereof or the 5,6,7,8 tetrahydro derivative of the formula ##STR2## wherein R.sub.1 is as defined under formula Ia and R.sub.2 is hydrogen, C.sub.1 -C.sub.4 -alkyl, halogen etherified or esterified hydroxy or mercapto, carboxy-C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxycarbonyl-C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkanoyl, to stereoisomers, mixtures of these stereoisomers and salts of these compounds are disclosed as well as their preparation, pharmaceutical compositions containing the same and the use thereof as inhibitors of aromatase activity.

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