Substituted hydroxyethylamine aspartyl protease inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S362000, C546S159000, C548S128000

Reexamination Certificate

active

07858642

ABSTRACT:
The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

REFERENCES:
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 5095006 (1992-03-01), Bender et al.
patent: 5132400 (1992-07-01), Gammill et al.
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5254595 (1993-10-01), Guzzi et al.
patent: 5362912 (1994-11-01), Sowin et al.
patent: 5387742 (1995-02-01), Cordell
patent: 5441870 (1995-08-01), Seubert et al.
patent: 5593846 (1997-01-01), Schenk et al.
patent: 5604102 (1997-02-01), McConlogue et al.
patent: 5612486 (1997-03-01), McConlogue et al.
patent: 5696270 (1997-12-01), Kempf et al.
patent: 5720936 (1998-02-01), Wadsworth et al.
patent: 5721130 (1998-02-01), Seubert et al.
patent: 5744346 (1998-04-01), Chrysler et al.
patent: 5766846 (1998-06-01), Schlossmacher et al.
patent: 5811633 (1998-09-01), Wadsworth et al.
patent: 5850003 (1998-12-01), McLonlogue et al.
patent: 5877015 (1999-03-01), Hardy et al.
patent: 5877399 (1999-03-01), Hsiao et al.
patent: 5892052 (1999-04-01), Kempf et al.
patent: 5912410 (1999-06-01), Cordell
patent: 5942400 (1999-08-01), Anderson et al.
patent: 6045829 (2000-04-01), Liversidge et al.
patent: 6150530 (2000-11-01), Kempf et al.
patent: 6191166 (2001-02-01), Audia et al.
patent: 6379666 (2002-04-01), Tobinick
patent: 7109217 (2006-09-01), Coburn et al.
patent: 2002/0019403 (2002-02-01), Hom et al.
patent: 2003/0096864 (2003-05-01), Fang et al.
patent: 2004/0044072 (2004-03-01), Tenbrink et al.
patent: 2005/0043290 (2005-02-01), Cumming et al.
patent: 2005/0119227 (2005-06-01), Cumming et al.
patent: 2006/0014737 (2006-01-01), John et al.
patent: 2007/0225372 (2007-09-01), Bueno Melendo et al.
patent: 0 279 707 (1988-08-01), None
patent: 0 375 560 (1990-06-01), None
patent: WO 98/22597 (1998-05-01), None
patent: WO 99/64001 (1999-12-01), None
patent: WO 00/17369 (2000-03-01), None
patent: WO 00/47618 (2000-08-01), None
patent: WO 01/10387 (2001-02-01), None
patent: WO 01/23533 (2001-04-01), None
patent: WO 02/02512 (2002-01-01), None
patent: WO 02/05804 (2002-01-01), None
patent: WO 02/09760 (2002-02-01), None
patent: WO 02/085877 (2002-10-01), None
patent: WO 02/098849 (2002-12-01), None
patent: WO 02/100399 (2002-12-01), None
patent: WO 02/100820 (2002-12-01), None
patent: WO 03/002122 (2003-01-01), None
patent: WO 03/006021 (2003-01-01), None
patent: WO 03/006423 (2003-01-01), None
patent: WO 03/029169 (2003-04-01), None
patent: WO 03/040096 (2003-05-01), None
patent: WO 03/050073 (2003-06-01), None
patent: WO 03/072535 (2003-09-01), None
patent: WO 2004/024081 (2004-03-01), None
patent: WO 2004/029019 (2004-04-01), None
patent: WO 2004/043916 (2004-05-01), None
patent: WO 2004/050609 (2004-06-01), None
patent: WO 2004/050619 (2004-06-01), None
patent: WO 2004/069793 (2004-08-01), None
patent: WO 2004/094384 (2004-11-01), None
patent: WO 2004/094413 (2004-11-01), None
patent: WO 2005/014517 (2005-02-01), None
patent: WO 2005/014540 (2005-02-01), None
patent: WO 2005/016876 (2005-02-01), None
patent: WO 2005/058915 (2005-06-01), None
patent: WO 2005/087714 (2005-09-01), None
patent: WO 2005/108358 (2005-11-01), None
patent: WO 2005/108391 (2005-11-01), None
Ajay, et al., “Designing libraries with CNS activity,” J. Med. Chem., (1999) 42, 4942-4951.
Albright, J.D., “Synthesis of 1,4,5,6,-Tetrahydropyrazolo[3,4-d]pyrido[3,2-b]azepine,” J. Heterocycl. Chem., (2000), 37, 41-46.
Alexakis et al., “A practical, solvent free, one-pot synthesis of C2-symmetrical secondary amines,” Tet. Lett. 2004, 45: 1449-1451.
Alvarez, A., et al., “Synthesis of 3-Arylpyrroles and 3-Pyrrolylacetylenes by Palladium-Catalyzed Coupling Reactions”, J. Org. Chem., (1992), 57, 1653-1656.
Anderson, G.W., et al., “Studies in Chemotherapy. X. Antithyroid Compounds. Synthesis of 5- and 6- Substituted 2-Thiouracils from b-Oxoesters and Thiourea,” J. Am. Chem. Soc., (1945), 67, 2197-2200.
Anzalone, L. and Hirsch, J.A., “Substituent Effects on Hydrogenation of Aromatic Rings: Hydrogenation vs. Hydrogenolysis in Cyclic Analogues of Benzyl Ethers,” J. Org. Chem., (1985), 50, 2128-2133.
Beam, C.F., et al., “Preparation of Pyrazoles from the C(α)NN-Trianion of Hyrdrazones having an α-Hydrogen Atom,” J. Chem. Soc., Section C: Organic (1971), 9, 1658-1660.
Becker, D.P. & Flynn, D.L., “A Short Synthesis of 1-Azaadamantan-4-one and the 4r and 4s Isomers of 4-Amino-l-azaadamantane,” Synthesis, (1992), 1080-1082.
Benedetti, et al., “Versatile and Stereoselective Synthesis of Diamino Diol Dipeptide Isosteres, Core Units of Psuedopeptide HIV Protease Inhibitors,” J. Org. Chem., (1997), 62, 9348-9353.
Boeckman, R. K., Jr.; Liu, X., “Controllable Monoaddition of Carbon Nucleophiles to 1,2,3,4-Diepoxybutane: Two-directional Chain Extension of a C2 Symmetric Four Carbon Diepoxide as a Route to Differentiated Syn 1,2-Diols,” Synthesis, (2002), 14, 2138-2142.
Castro, B., et al., “Reactifs de Couplage Peptidique IV (1)—L'Hexaflourophosphate De Benzotriazolyl N-Oxytrisdimethylamino Phosphonium (B.O.P.),” Tet. Letters, (1975), 14, 1219-1222.
Cerri, A., et al., “17beta-O-Aminoalkyloximes of 5beta-androstane-3beta,14beta-diol with digitalis-like activity: synthesis, cardiotonic activity, structure-activity relationships, and molecular modeling of the Na(+),K(+)-ATPase receptor.,” J. Med. Chem.; 2000, 43, 2332-2349.
Citron, et al., “Mutation of the B-amyloid precursor protein in familial Alzheimer's disease increases B-protein production,” Nature, (1992), 360:672-674.
Copending U.S. Appl. No. 11/038,790, filed Jan. 21, 2005, published Jan. 19, 2006.
U.S. Appl. No. 11/074,828, filed Mar. 9, 2005, published Oct. 27, 2005.
U.S. Appl. No. 11/075,292, filed Mar. 9, 2005, published Nov. 24, 2005.
Copending U.S. Appl. No. 11/075,294, filed Mar. 9, 2005, published Oct. 27, 2005.
Copending U.S. Appl. No. 11/075,445, filed Mar. 9, 2005, published Jan. 19, 2006.
U.S. Appl. No. 11/177,324, filed Jul. 11, 2005, published Jun. 22, 2006, issued as U.S. Patent No. 7,385,085.
Copending U.S. Appl. No. 11/177,348, filed Jul. 11, 2005, published Jun. 15, 2006.
Copending U.S. Appl. No. 11/211,484, filed Aug. 26, 2005, published Apr. 6, 2006.
Copending U.S. Appl. No. 11/546,347, filed Oct. 12, 2006, published Jun. 28, 2007.
Copending U.S. Appl. No. 11/659,788, filed Aug. 21, 2007, published Jul. 10, 2008.
Copending U.S. Appl. No. 12/117,094, filed May 8, 2008, published Feb. 12, 2009.
Coria F. and Rubio, I., “Cerebral amyloid angiopathies,” Neuropath Appl. Neurobiol., (1996) 22, 216-227.
Cornelius, L.A.M.; Combs, D.W., “A Convenient Synthesis of Mono- and Polyhalogenated Benzocyclanones,” Synthetic Communications, (1994), 24, 2777-2788.
Dai, C. and Fu, G.J., “The first general method for palladium-catalyzed Negishi cross-coupling of aryl and vinyl chlorides: use of commercially available Pd(P(t-Bu)(3))(2) as a catalyst,” J. Am. Chem. Soc., (2001), 123, 2719-2724.
Dantzig, A.H., et al., “Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979,” Cancer Research, (1996), 56, 4171-4179.
Dovey, et al., “Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain,” J. Neurochemistry, (2001), 76:173-181.
Emilien, G., et al., “Prospects for Pharmacological Intervention in Alzheimer Disease,” Arch. Neurol. (2000), 57:454-459.
Ertl, P., et al., “Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties,” J. Med. Chem., (2000), 43:3714-3717.
Fujita, T., et al., “A new substituent constant, pie-derived from

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