Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-12-04
2007-12-04
Coleman, Brenda (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S217060, C514S217070, C514S217090, C514S217100, C540S597000, C540S599000, C540S600000, C540S603000
Reexamination Certificate
active
10169011
ABSTRACT:
The present invention relates to compounds of formula (I)their prodrugs, N-oxides, addition salts, quaternary amines and stereochemically isomeric forms, wherein the bivalent radical -{circle around (A)}- represents a saturated or an unsaturated homopiperidinyl having one double bond, and wherein said bivalent radical -{circle around (A)}- is substituted with R2being hydrogen, hydroxy, C1-4alkyl, or C1-4alkyloxy; -a1=a2-a3=a4- represents an optionally substituted bivalent radical; R1is hydrogen, C1-6alkyl, aryl1, C1-6alkyl substituted with aryl1, C1-4alkyloxycarbonyl, aryl1carbonyl, aryl1C1-6alkylarbonyl C1-4alkylcarbonyl, trifluoromethyl, trifluoromethylcarbonyl, C1-6alkylsulfonyl, aryl1sulfonyl, methanesulfonyl, benzenesulfonyl, trifluoromethanesulfonyl, dimethylsulfamoyl; X represents O, S or NR3, wherein R3is hydrogen, C1-6alkyl, methanesulfonyl, benzenesulfonyl, trifluoromethanesulfonyl, dimethylsulfamoyl, C1-4alkyl substituted with aryl2and optionally with hydroxy, C1-4alkylcarbonylC1-4alkyl substituted with aryl2; aryl1is optionally substituted phenyl, optionally substituted pyridinyl, naphthyl, quinolinyl, or 1,3-benzodioxolyl; aryl2is optionally substituted phenyl; fundic relaxating activity. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating dyspeptic symptoms, irritable bowel syndrome and other conditions related to a hampered or impaired relaxation of the fundus.
REFERENCES:
patent: 3781297 (1973-12-01), Pawellek et al.
patent: 4093726 (1978-06-01), Winn et al.
patent: 2 060 197 (1972-06-01), None
patent: 0 079 545 (1983-05-01), None
patent: 0 580 541 (1994-01-01), None
patent: WO 01/46189 (2001-06-01), None
Orajales, Aurelio et al.,Synthesis and Structure-Activity Relationship of New Piperidinyl and Piperazinyl Derivatives as Antiallegics, J. Heterocyclic Chem., vol. 32, May-Jun. 1995, pp. 707-718.
John J. D'Amico et al., 2-Substituted Thiobenzothiazole and Related Compounds, I. Novel Methods for the Preparation of 2,2′-Thiobis(benzothiazoles),2-(N,N-Disubstituted amino)benzothiazoles, and Related Compounds,J. Org. Chem., vol. 30, Nov. 1965, pp. 3618-3625.
Muftic, Dr. Mahmoud,Neue Substanzen Mit Komplementbindungshemmender Wirkungin Vitro, Quart. J. Crude Drug Res., vol. 9, No. 3, 1969, pp. 1422-1425.
Chernova, Y. et al.,Synthesis and Biological Activity of 5,6-Dinitro Derivatives of Benzimidazole, Khim.-Farm. ZH, vol. 25, 1991, pp. 50-52.
International Search Report (PCT), 2001.
Guillemont Jérôme Emile Georges
Janssens Frans Eduard
Sommen François Maria
Janssen Pharmaceuitca N.V.
Woodcock & Washburn LLP
LandOfFree
Substituted homopiperidinyl benzimidazole analogues as... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted homopiperidinyl benzimidazole analogues as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted homopiperidinyl benzimidazole analogues as... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3833357