Substituted hexahydrobenzo[e]indene and octahydrophenanthrene CN

Details Substituted hexahydrobenzo[e]indene and octahydrophenanthrene CN Substituted hexahydrobenzo[e]indene and octahydrophenanthrene CN

1984-06-07

1986-03-18

Helfin, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514548, 514680, 514719, 514732, 568326, 568633, 568660, 568733, 560139, 560255, A61K 3122, C07C 4310, C07C 43205

Patent

active

045769648

ABSTRACT:
Tricyclic benzo fused compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, wherein n is zero, 1 or 2, and t is 1 or 2; M is CH or N, R.sub.1 is H or certain acyl groups; Q is CO.sub.2 R.sub.4, COR.sub.5, C(OR.sub.7)R.sub.5 R.sub.6, CN, CONR.sub.9 R.sub.10, CH.sub.2 NR.sub.9 R.sub.10, CH.sub.2 NHCOR.sub.11, CH.sub.2 NHSO.sub.2 R.sub.12, 5-tetrazolyl or when n is 1, Q and OR.sub.1 together form a lactone or certain reduced derivatives thereof; and Z is certain alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl groups, are valuable central nervous system active agents, methods for their use, pharmaceutical compositions containing them and certain intermediates therefor.

REFERENCES:
patent: 4188495 (1980-02-01), Althuis et al.
patent: 4476131 (1984-10-01), Eggler et al.

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