Substituted heterocyclic derivatives useful as antidiabetic...

Details Substituted heterocyclic derivatives useful as antidiabetic... Substituted heterocyclic derivatives useful as antidiabetic...

2007-10-09

2007-10-09

Tucker, Zachary C (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S374000, C544S297000, C548S235000

Reexamination Certificate

active

10616365

ABSTRACT:
Substituted heterocyclic derivatives are provided which have the structurewherein Z1is (CH2)qor C═O;Z2is (CH2)por C═O;D is —CH═ or C═O or (CH2)mwhere m is 0, 1, 2 or 3;n=0, 1 or 2; p=1 or 2; q=0, 1 or 2;Q is C or N;X is CH or N;X2is C, N, O or S;X3is C, N, O or S;X4is C, N, O or S;X5is C, N, O or S;X6is C, N, O or S;provided that at least one of X2, X3, X4, X5and X6is N; and at least one of X2, X3, X4, X5and X6is C;A, B, R1, R2, R2a, R2b, R4, R3, E, Z and Y are as defined herein.In addition, a method is provided for treating diabetes, Type 2 diabetes, insulin resistance, hyperglycemia, hyperinsulinemia, elevated blood levels of fatty acids or glycerol, hyperlipidemia, obesity, hypertriglyceridemia, Syndrome X, or atherosclerosis, wherein the substituted heterocyclic derivatives are administered in a therapeutically effective amount to a patient.

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