Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-11-21
1997-04-08
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 19, 514362, 514363, 514364, 514383, 530331, 548128, 548131, 548136, 548143, 5482668, A61K 3138, A61K 31535, A61K 3154, A61K 3806
Patent
active
056187920
ABSTRACT:
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases including human neutrophil elastase, equivalently known as human leukocyte elastase.
REFERENCES:
patent: 4338453 (1982-07-01), Gall
patent: 5055450 (1991-10-01), Edwards et al.
patent: 5164371 (1992-11-01), Edwards et al.
Budavari et al., eds., The Merck Index, 11th ed., published 1989 by Merck & Co., Inc. (Rahway), p. 1924.
Bernstein, P. R., et al., "Nonpeptide Inhibitors of Human Leukocyte Elastase. 3. Design, Synthesis, X-Ray Crystallographic Analysis, and Structure-Activity Relationships for a Series of Orally Active 3-Amino-6-Phenylpyridin-2-one Trifluoromethyl Ketones," J. Med. Chem., 37, 3313-3326 (1994).
Brown, F. J., et al. "Design of Orally Active, Non-Peptidic Inhibitors of Human Leukocyte Elastase" J. Med. Chem., 37, 1259-1261 (1994).
Damewood, J. R., et al., "Nonpeptide Inhibitors of Human Leukocyte Elastase. 2. Design, Synthesis, and in Vitro Activity of a Series of 3-Amino-6-Phenylpyridin-2-one Trifluoromethyl Ketones," J. Med. Chem., 37, 3303-3312 (1994).
Schechter, I., et al., "On the Size of the Active Site in Proteases. I. Papain," Biochem. Biophys. Res. Comm., 27., 157-162 (1967).
Schechter, I., et al., "On the Active Site of Proteases. III. Mapping the Active Site of Papain; Specific Peptide Inhibitors of Papain," Biochem. Biophys. Res. Comm., 32, 898-902 (1968).
Tsutsumi, S., et al., "Synthesis and Structure-Activity Relationships of Peptidyl .alpha.-Keto Heterocycles as Novel Inhibitors of Prolyl Endopeptidase,"J. Med. Chem., 37, 3492-3502 (1994).
Warner, P., et al., "Non-peptidic Inhibitors of Human Leukocyte Elastase. 1. The Design and Synthesis of Pyridone-Containing Inhibitors," J. Med. Chem., 37, 3090-3099 (1994).
Gyorkos Albert
Spruce Lyle W.
Burke John
Cortech Inc.
Russel Jeffrey E.
LandOfFree
Substituted heterocyclic compounds useful as inhibitors of (seri does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted heterocyclic compounds useful as inhibitors of (seri, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted heterocyclic compounds useful as inhibitors of (seri will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2397778