Substituted heterocyclic compounds useful as inhibitors of (seri

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 19, 514362, 514363, 514364, 514383, 530331, 548128, 548131, 548136, 548143, 5482668, A61K 3138, A61K 31535, A61K 3154, A61K 3806

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056187920

ABSTRACT:
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases including human neutrophil elastase, equivalently known as human leukocyte elastase.

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Tsutsumi, S., et al., "Synthesis and Structure-Activity Relationships of Peptidyl .alpha.-Keto Heterocycles as Novel Inhibitors of Prolyl Endopeptidase,"J. Med. Chem., 37, 3492-3502 (1994).
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