Substituted heterocyclic compounds and the pharmacologically acc

Details Substituted heterocyclic compounds and the pharmacologically acc Substituted heterocyclic compounds and the pharmacologically acc

1989-03-10

1990-06-26

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544105, 544173, 544353, 544 585, 5142242, 5142282, 5142338, 514213, 514215, 514221, 5142305, 540552, 546159, 548465, C07D29500, C07D26536, C07D26530, C07D20902

Patent

active

049373374

ABSTRACT:
The present invention provides compounds of the general formula: ##STR1## wherein R.sub.1 is a straight-chained or branched C.sub.1 -C.sub.12 -alkyl radical which can be substituted by a phenyl, naphthyl or C.sub.3 -C.sub.7 -cycloalkyl radical, a straight-chained or branched C.sub.2 -C.sub.12 -alkenyl radical which can be substituted by a C.sub.3 -C.sub.7 -cycloalkyl, phenyl or naphthyl radical, a C.sub.3 -C.sub.7 -cycloalkyl radical or an unsubstituted or mono- or polysubstituted mono- or bicyclic aromatic radical, in which the substituents can be halogen atoms, carboxyl groups or C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or C.sub.1 -C.sub.4 -alkoxycarbonyl radicals, R.sub.2 and R.sub.3, which can be the same or different, are straight-chained, branched, saturated or unsaturated C.sub.1 -C.sub.6 -alkyl radicals or, together with the nitrogen atom to which they are attached, form a saturated or unsaturated ring which can contain further heteroatoms and can possibly be substituted by a C.sub.1 -C.sub.6 -alkyl radical, one or more C.sub.1 -C.sub.6 -alkoxy radicals, one or more hydroxyl groups or by an oxygen atom, X is a methylene radical, an oxygen or sulphur atom, a sulphoxide or sulphonyl group or an .dbd.NR.sub.6 group, in which R.sub.6 is a hydrogen atom or a C.sub.1 -C.sub.4 -alkyl or aralkyl radical, n is 0, 1 or 2, k is 0, 1, 2 or 3, R.sub.4 is a halogen atom, a hydroxyl group or a C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy or aralkoxy radical or, when k is 2, is a C.sub.1 -C.sub.2 -alkylenedioxy radical on two adjacent carbon atoms, m is 0, 1, 2 or 3 and R.sub.5 is a halogen atom, a hydroxyl group or a C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy or aralkoxy radical or, when m is 2, is a C.sub.1 -C.sub.2 -alkylenedioxy radical on two adjacent carbon atoms; as well as the pharmacologically acceptable salts thereof.
The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.

REFERENCES:
patent: 3535338 (1970-10-01), Krapcho
patent: 3632805 (1972-01-01), Yamamoto
patent: 3953469 (1976-04-01), Krapcho
patent: 4255430 (1981-03-01), Koppe et al.

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