Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-04-11
2006-04-11
Owens, Amelia A. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S254020, C514S338000, C514S340000, C514S342000, C544S367000, C544S368000, C544S369000, C546S268400, C546S269100, C546S270100
Reexamination Certificate
active
07026321
ABSTRACT:
Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.
REFERENCES:
patent: 4558129 (1985-12-01), Kluge et al.
patent: 4567264 (1986-01-01), Kluge et al.
patent: 4723014 (1988-02-01), Anderson et al.
patent: 4766125 (1988-08-01), Van Daele et al.
patent: 4820842 (1989-04-01), Anderson et al.
patent: 5112817 (1992-05-01), Fukazawa et al.
patent: 5204348 (1993-04-01), Fukazawa et al.
patent: 5405843 (1995-04-01), Fukazawa et al.
patent: 5472707 (1995-12-01), Samuels et al.
patent: 5506229 (1996-04-01), Dow et al.
patent: 5906988 (1999-05-01), Dow
patent: 6451798 (2002-09-01), Varkhedkar et al.
patent: 6552023 (2003-04-01), Zablocki et al.
patent: 6573264 (2003-06-01), Zablocki et al.
patent: 6638970 (2003-10-01), Elzein et al.
patent: 6677336 (2004-01-01), Zablocki et al.
patent: 6677343 (2004-01-01), Blackburn et al.
patent: 2003/0181352 (2003-09-01), Ibrahim et al.
patent: 0 268 273 (1988-05-01), None
patent: 0 363 212 (1990-04-01), None
patent: 0 407 780 (1991-01-01), None
patent: 0 483 392 (1992-06-01), None
patent: 03 141258 (1991-06-01), None
patent: WO 01/62749 (2001-08-01), None
patent: WO 02/32902 (2002-04-01), None
Berthold, R. et al ‘3-Aminopropoxyaryl derivatives’ CA 105:172505 (1986).
Fan, Y. et al ‘Syntheses of 1-(2-hydroxy-3-aryloxypropyl)-4-aryolpiperazines’ CA 108:5971 (1988).
U.S. Appl. No. 10/729,499, Jiang et al.
McCormick, et al. “Ranolazine: A Novel Metabolic Modulator for the Treatment of Angina”, Gen Pharmac., vol. 30, No. 5, pp. 639-645, (1998).
Suzuki T et al: “Structure-activity relationship of newly synthesized quinoline derivatives for reversal of multidrug resistance in cancer.”, Journal of Chemistry, vol. 40, No. 13, 1997, pp. 2047-2052, XP000924067, the whole document, particularly p. 2049, table 2, compound 5.
Zacharowski K et al: “Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat.” European Journal of Pharmacology, vol. 418, No. 1-2, Apr. 20, 2001, pp. 105-110, XP002215620, the whole document.
Lopaschuk G D: “Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism”, The American Journal of Cardiology, vol. 82, No. 5A, Sep. 3, 1997, pp. 14K-17K, XP002215621, the whole document.
Elzein Elfatih
Ibrahim Prabha
Jiang Robert
Marquart Tim
Palle Venkata
CV Therapeutics Inc.
Hartrum J. Elin
Lewis Brian
Owens Amelia A.
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