Substituted heterocyclic carboxyamides, their preparation and th

Details Substituted heterocyclic carboxyamides, their preparation and th Substituted heterocyclic carboxyamides, their preparation and th

1994-12-28

1997-04-15

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546296, 546298, C07D21365, C07D21389, A61K 3144

Patent

active

056209959

ABSTRACT:
The invention relates to compounds of the formula I, to a process for their preparation and to their use as pharmaceuticals. ##STR1## In particular, the compounds are used as inhibitors of prolyl-4-hydroxylase and as inhibitors of collagen biosynthesis, as pharmaceuticals against fibrotic diseases of the liver, the lung and the skin.

REFERENCES:
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Gunhild Kaule et al., "Assay for 2-Oxoglutarate Decarboxylating Enzymes Based on the Determination of [1-14-C] Succinate: Application to Prolyl 4-Hydroxylase" Analytical Biochemistry, 184, pp. 291-297 (1990).
Georges Jolles, et al. "No. 354.--Pristinamycine. Synth e de L'heptapeptide Lin eaire et d'oligopeptides correspondant au constituant IA de la Pristinamycine" M emoires Pr esent es a la Soci et e Chimique, pp. 2252-2259 (1965).
Search Report for EP94120766.4, 13 Apr. 1995.
G. Jolles, et al., Bulletin de la Societe Chimique ee France, No. 8, 1965, pp. 2252-2259, with CAS RN 3458-69-3 attachment.
R. J. Bergeron, et al., Journal of Medicinal Chemistry, vol. 37, No. 18, 1994, pp. 2889-2895.
Chemical Abstracts, vol. 115, No. 21, 1991, Abstract No. 222778s with attachment; CAS RN 136868-58-1 and CAS RN 136868-59-2.
Chemical Abstracts, vol. 95, No. 17, 1981, Abstract No. 151135k with attachment: CAS RN 77431-62-0, CAS RN 77421-44-0 and CAS RN 77421-43-3.
T. J. Franklin, Biochem Soc Trans, vol. 19(4), pp. 812-815, 1991.
R. J. Bergeron, J Med Chem, vol. 37, pp. 2889-2895, 1994.

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