Substituted heterocyclic carboxamide esters, their preparation a

Details Substituted heterocyclic carboxamide esters, their preparation a Substituted heterocyclic carboxamide esters, their preparation a

1994-10-31

1997-08-19

Davis, Zinna Northington

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544223, 544235, 544239, 546141, 546147, 546143, 546156, 546161, 546169, 546298, 546310, 546323, 514248, 514252, 514307, 514309, 514310, 514311, 514312, 514313, 514352, 514354, C07D21381, A61K 31455

Patent

active

056589336

ABSTRACT:
The invention relates to compounds of the formula I, ##STR1## to a process for their preparation and to their use as pharmaceuticals. The compounds are employed, in particular, as ester prodrugs of prolyl hydroxylase inhibitors for inhibiting collagen biosynthesis and as fibrosuppressive agents.

REFERENCES:
patent: 5192773 (1993-03-01), Armistead et al.
patent: 5204338 (1993-04-01), Baader et al.
John T. Sheehan, 3-Hydroxypicolinic Acid and Some of Its Derivatives, Journal of Organic Chemistry, vol. 31, Feb. 1966, pp. 636-638.
Horst Kessler et al., `Synthese des Benzylethers von Virginiamycin S1` Liebigs Annalen Der Chimie., Nr. 1, 1986, pp. 1-20.

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