Substituted heterocycles, their use as medicament, and...

Details Substituted heterocycles, their use as medicament, and... Substituted heterocycles, their use as medicament, and...

2007-12-12

2010-11-02

Saeed, Kamal A (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S243000, C546S278400, C546S152000, C548S214000, C514S212030, C514S343000, C514S423000, C514S372000, C514S315000

Reexamination Certificate

active

07825264

ABSTRACT:
The invention relates to compounds of formula Iin which A, R1, R2, R3, R4, R5, R6, R7 and n have the meanings stated in the claims. The compounds are particularly suitable as antiarrhythmic active ingredients, in particular for the treatment and prophylaxis of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.

REFERENCES:
patent: 5629322 (1997-05-01), Guthikonda et al.
patent: WO 9614844 (1996-05-01), None
Moehrle et al Zeitschrift Fuer Naturforschung, B: Chemical Science 58(6) 585-594 (2003).
Sahasrabudhe et al Journal of the American Chemical Society 125(26), 7914-7922 (2003).
Brendel, et al., Blockers of the Kv1.5 channel for the treatment of atrial arrhythmias, Expert Opinion of therapeutic Patents; 2002; V.12, No. 11, pp. 1589-1598.
Hashimoto, et al., Stereoselective synthesis of optically active .beta.-lactams by the reaction of chiral imines derived from erythro-2-amino-1, 2-diphenytethanol with ester enolates, Heterocycles; 2000, 52(3); p. 1003.
Sahasrabudhe, et al., Asymetric Schmidt reaction of hydroxyalkyl azides with ketones, J. of the Amer. Chem. Soc., 2003, 125(26), pp. 7914-7922.

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