Substituted guanidines having high binding to the sigma receptor

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514256, 514336, 514349, 514351, 514365, 514370, 514374, 514377, 514392, 514422, 514426, 514432, 514469, 514471, 514472, A61K 31495, A61K 31505, A61K 3144, A61K 3141, A61K 3142, A61K 31415, A61K 3140, A61K 3138, A61K 3134

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active

056042280

ABSTRACT:
N,N-disubstituted-guanidines, e.g., of the formula ##STR1## wherein R and R' are substituted or unsubstituted hydrocarbon groups. Methods are provided for the treatment of psychosis and hypertension by administering an effective amount of an N,N'-disubstituted guanidine which, preferably, has a high affinity for the sigma receptor.

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