Substituted guanidines and diaminonitroethenes, their preparatio

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514609, 546330, 546332, 564104, A61K 3144, A61K 3116

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active

061470988

ABSTRACT:
Guanidine and diaminonitroethene derivatives represented by the formula ##STR1## wherein X, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined in the description, compositions thereof and methods for preparing the compounds are described. The se compounds are useful in the treatment of diseases of the central nervous system, cardiovascular system, pulmonary system, gastrointestinal system and endocrinologic system.

REFERENCES:
patent: 4567188 (1986-01-01), Niemers et al.
patent: 5087640 (1992-02-01), Morita et al.
Yoshizumi et al., Chem. Abst. 126:74528, 1996.
Myamoto et al., Chem Abst. 123:321699, 1995.
Yoshiizumi et al., Chem Pharm. Bull., vol. 44, No. 11, pp. 2042-2050 (1996).
Belezertseva et al. Chem Abst. 127:262499 (1997).
Abstract of Japanese patent application 06028936.
Abstract of Japanese patent application 3-244901 (Jan. 31, 1994).

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