Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1992-02-10
1995-04-04
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514150, 514519, 514506, 514588, 514616, 514623, A61K 31155, A61K 3117, A61K 3116, A61K 31165
Patent
active
054038618
ABSTRACT:
Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.
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Fischer James B.
Goldin Stanley M.
Hu Lain-Yen
Katragadda Subbarao
Knapp Andrew G.
Cambridge NeuroScience, Inc.
Cebulak Mary
Conlin David G.
Corless Peter F.
Raymond Richard L.
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