Substituted guandines and methods of preparation thereof

Details Substituted guandines and methods of preparation thereof Substituted guandines and methods of preparation thereof

1980-07-14

1982-03-09

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

564170, 564182, 548315, 424324, A01K 31165, A01K 31415, C07C12912, C07D23348

Patent

active

043189156

ABSTRACT:
A compound of the formula ##STR1## wherein R.sup.1 is chlorine, bromine, or methoxy; and R.sup.2, R.sup.3, and R.sup.4 are individually hydrogen or methyl, at least one of R.sup.2, R.sup.3, and R.sup.4 being hydrogen; or R.sup.2 and R.sup.3 together are an ethylene group and R.sup.4 is hydrogen, or a pharmaceutically acceptable acid addition salt thereof. Such compounds are useful as anti-hypertensive agents. Methods of preparation and certain novel intermediates are also disclosed.

REFERENCES:
patent: 3632645 (1972-01-01), Bream et al.
patent: 3634508 (1972-01-01), Bream et al.
patent: 3822262 (1974-07-01), Bream et al.

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