Substituted fused and bridged bicyclic compounds as therapeutic

Details Substituted fused and bridged bicyclic compounds as therapeutic Substituted fused and bridged bicyclic compounds as therapeutic

1995-02-23

1996-12-10

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

549369, 560 52, 560 56, 562460, C07D48700, C07C 6976, A01N 4346, A01N 3710

Patent

active

055832210

ABSTRACT:
Compounds having the formula ##STR1## methods for using such compounds to inhibit protein kinase C in animals, including man are useful as inhibitors of protein kinase C. Also disclosed are pharmaceutical compositions including such compounds and compounds having the formula.

REFERENCES:
CA122:81925 1994.
CA121:300627 1994.
CA121:280445 1994.
CA119:249745 1993.
Kikkawa, et al., "Rapid Purificatiion of Protein Kinase C by High Performance Liquid Chromatography", Biochem. Biophys. Res. Comm., 1986, 135, 636.
McArdle, et al., "Use of Protein Kinase C-Depleted Cells for Investigation of the Role of Protein Kinase C in Stimulus-Response Coupling in the Pituitary", Methods Enzym., 1989, 168, 287.
Osada, et al., "Rapid Screening Method for Inhibitors of Protein Kinase C", J. Antibiotics, 1988, 41, 547.
Mendoza et al., "Synthesis and Biological Evaluation of Conformationally Constrained Bicyclic Balanol Analogues as Inhibitors of Protein Kinase C" Presented to the Washington D.C. ACS Meeting, Aug. 21, 1994.
Atini, D., et al., Amides and Amines with Analgesic and Antiniflammatory Activity, 1971, 21(1), 30-6.

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