Substituted enaminones, their derivatives and uses thereof

Details Substituted enaminones, their derivatives and uses thereof Substituted enaminones, their derivatives and uses thereof

2006-06-15

2010-10-26

Davis, Zinna N (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S252100, C514S255050, C514S257000, C514S310000, C514S311000, C514S352000, C514S359000, C514S364000, C514S381000, C514S383000, C514S372000, C514S378000, C514S374000, C514S406000, C544S224000, C544S329000, C544S406000, C546S146000, C546S159000, C546S304000, C548S133000, C548S143000, C548S212000, C548S222000, C548S253000, C548S268400, C548S367400

Reexamination Certificate

active

07820663

ABSTRACT:
The present invention is related substituted enaminones represented by a compound of Formula I that are novel allosteric modulators of α7 nAChRs. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on α7 nAChRs in a mammal by administering an effective amount of a compound of Formula I.

REFERENCES:
patent: 294250 (1991-09-01), None
patent: WO 2004/052889 (2004-06-01), None
patent: WO 2004/085433 (2004-10-01), None
patent: WO 2005/108347 (2005-11-01), None
Eiden et al, Archiv der Pharmazie, 1986, 319(3), pp. 242-251.
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 & 365.
Hauser et al, Journal fuer Praktische Chemie (Leipzig) (1977), 319(2), pp. 263-273.
Fischer, et al, Journal of Heterocyclic Chemistry (1996), 33(3), pp. 815-823.
English Translation of DD 294250 A5, Fischer et al, Sep. 1991.
Dains, et al., “The Reactions of the Formamidines. III. On the Synthesis of Isoxazole, Cyanoacetic and Benzoylacetic Derivatives”, J. Am. Chem. Soc., vol. 35, 1913, pp. 959-970.
Dains, et al., “On the Reactions of the Formamidines. V. On Some Pyrazolone Derivatives”, J. Am. Chem. Soc., vol. 38, 1916, pp. 1510-1517.
Goerdeier J., et al., “Herstellung Und Konformation Von Vinylogen Harnstoffen Preparation and Conformation of Vinylogous Ureas” vol. 113, No. 7, 1980, pp. 2499-2508.
Moszew, et al., “Reaction of Diphenylformamidine with Anilides of beta-ketoacids. Part 1”, vol. 14, 1969, pp. 89-94.

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