Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-01-20
1989-11-14
Siegel, Alan
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514438, 549 65, 549 77, A61K 3138, C07D33322
Patent
active
048808296
ABSTRACT:
The invention relates to novel substituted tyrosyl alanine dipeptide amides of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sup.1 is hydrogen, lower alkyl, hydroxy, --OCO.sub.2 lower alkyl, lower alkoxy, --O(CH.sub.2).sub.n --phenyl with the phenyl optionally substituted by halogen, --NO.sub.2, --CN, --NH.sub.2 or lower alkyl wherein n is 1 to 4; R.sup.2 and R.sup.3 represent lower alkyl, halogen, or lower alkoxy, or either one of R.sup.2 or R.sup.3 is hydrogen and the other is lower alkyl, lower alkoxy or halogen; R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, and R.sup.9 may be the same or different and represent hydrogen or lower alkyl; R.sup.10 is selected from the group consisting of
REFERENCES:
patent: 4127535 (1978-11-01), Coy et al.
patent: 4261888 (1981-04-01), Bauer et al.
patent: 4273704 (1981-06-01), Mazur
patent: 4316892 (1982-02-01), Jones
patent: 4405607 (1983-09-01), Cardinaux et al.
patent: 4407746 (1983-10-01), Mazur et al.
patent: 4450155 (1984-05-01), Morgan
patent: 4454120 (1984-06-01), Morgan
patent: 4533655 (1985-08-01), Morgan
patent: 4533657 (1985-08-01), Morgan
patent: 4599325 (1986-07-01), Hansen et al.
patent: 4758675 (1988-07-01), Hansen et al.
Clare Michael
Hamilton Robert W.
Hansen, Jr. Donald W.
Pitzele Barnett S.
G. D. Searle and Company
Grassler Frank R.
Matukaitis Paul D.
Siegel Alan
LandOfFree
Substituted dipeptide amides #3 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted dipeptide amides #3, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted dipeptide amides #3 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1853237