Substituted dihydroquinazolines

Details Substituted dihydroquinazolines Substituted dihydroquinazolines

2007-03-27

2007-03-27

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S284000

Reexamination Certificate

active

10832109

ABSTRACT:
The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.

REFERENCES:
patent: 2006/0211683 (2006-09-01), Selliah et al.
patent: 1201765 (2002-02-01), None
Martinez, A., Gil, C., Castro, A., Bruno, A., Pérez, C., Prieto, C., Otero, J., “Benzothiadiazine dioxide human cytomegalovirus inhibitors: synthesis and antiviral evaluation of main heterocycle modified derivatives,” Antiviral Chem. Chemo., 14: 107-114 (2003).
Gribaudo, G., Riera, L., Lembo, D., De Andrea, M., Johnson, L., Landolfo, S., “The anticytomegaloviral activity of raltitrexed is abrogated in quiescent mouse fibroblasts that overexpress the thymidylate synthase,” Virus Research, 73: 57-65 (2001).
Saito, et al., “A Facile and Efficient Carbodiimide-Mediated Synthesis of Dihydroquinazolines via a Tandem Nucleophilic Addition-Intramolecular Hetero Conjugate Addition Annulation Strategy,” Tet. Letts., 37(2): 209-212 (1996).
Wang, et al., “Solid-Phase Synthesis of 3,4-Dihydroquinazoline,” Tet. Letts., 38(50): 8651-8654 (1997).

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