Substituted dihydropyrano indole-3,4-dione derivatives as...

Details Substituted dihydropyrano indole-3,4-dione derivatives as... Substituted dihydropyrano indole-3,4-dione derivatives as...

2006-06-05

2008-12-02

Shameem, Golam M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S469000, C548S492000, C548S493000, C514S415000

Reexamination Certificate

active

07459478

ABSTRACT:
Compounds of formula (I) and II) are providedwherein: X is an alkali metal or a basic amine moiety; R1is alkyl, cycloalkyl, —CH2-cycloalkyl, pyridinyl, —CH2-pyridinyl, phenyl or benzyl, the rings of these groups being optionally substituted; R2is H, halogen, alkyl, perfluoroalkyl, alkoxy, cycloalkyl, —CH2-cycloalkyl, —NH2, or —NO2; R3is phenyl, benzyl, benzyloxy, pyridinyl, or —CH2-pyridinyl, with the rings of these groups being optionally substituted; or a pharmaceutically acceptable salt or ester form thereof, as well as pharmaceutical compositions and methods using these compounds as inhibitors of plasminogen activator inhibitor-1 (PAI-1) and as therapeutic compositions for treating conditions resulting from fibrinolytic disorders such as deep vein thrombosis and coronary heart disease, and pulmonary fibrosis.

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