Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-03-30
1999-11-30
Huang, Evelyn Mei
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 81, A61K 3144, C07D47104
Patent
active
059943653
ABSTRACT:
Novel diazaanthracenes of formula wherein the dotted line in the central ring indicates that either the central ring is aromatically unsaturated, and in this case either R.sup.3 or H is absent from the 10-position and either R.sup.4 or H is absent from the 5-position, or the central ring is saturated and R.sup.3 and H and R.sup.4 and H are present, and the corresponding 5,10-diones, N-oxides, N-halides, N-amine, salts, dimers, Diels-Alder adducts, carbene adducts and complexes with transition metal compounds display valuable antibacterial, anticancer and antifungal properties. The compounds of formulae (I) and (II) in which R.sup.1 and R.sup.2 are both methyl groups can be obtained by subjecting 3,5-lutidine to the effect of a strong reducing agent, for example molten sodium.
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Iyer Subramanian Sethuraman
Zaworotko Michael John
Browning Clifford W.
Diazans Limited
Huang Evelyn Mei
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