Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2005-08-12
2008-11-11
Balasubramanian, Venkataraman (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C544S207000, C544S208000
Reexamination Certificate
active
07449575
ABSTRACT:
This invention concerns the compounds of formulathe pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R1and R2are each independently selected from hydrogen; hydroxy; amino; optionally substituted C1-6alkyl; C1-6alkyloxy; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; Ar1; mono- or di(C1-6alkyl)amino; mono- or di(C1-6alkyl)-aminocarbonyl; dihydro-2(3H)-furanone; or R1and R2taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-6alkyl)amino-C1-4alkylidene; R3is hydrogen, Ar1, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxy-carbonyl, C1-6alkyl substituted with C1-6alkyloxycarbonyl; and R4, R5, R6, R7and R8are each independently selected from hydrogen, halo, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is optionally substituted C1-10alkyl; C3-10alkenyl; C3-10alkynyl; C3-7cycloalkyl; Ar1is optionally substituted phenyl; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them.
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Chem. Abstracts, 10th Collective Chemical Substance Index, 1977-1981, 88:191532z.
Chem. Abstracts, 10th Collective Chemical Substance Index,, 1977-1981, 86:140514w.
Chem. Abstracts, 10th Collective Chemical Substance Index,, 1977-1981, 86:171887z.
Chem. Abstracts, 10th Collective Chemical Substance Index,, 1977-1981, 87:184445z.
Chem. Abstacts, 10th Collective Chemical Substance Index,, 1977-1981, 87:289:44281j.
Chem. Abstracts, 10th Collective Chemical Substance Index,, 1977-1981, 87:39869m.
Chem. Abstracts, 10th Collective Chemical Substance Index,, 1977-1981, 89:6595g.
Chem. Abstracts, 10th Collective Chemical Substance Index,, 1977-1981, 90:137776k.
Chem. Abstracts, 10th Collective Chemical Substance Index,, 1977-1981, 91:92058e.
Chem. Abstracts, 10th Collective Chemical Substance Index,, 1977-1981, 92:147448k.
Chem. Abstracts, 10th Collective Chemical Substance Index,, 1977-1981, 93:186300w.
Chem. Abstracts, 10th Collective Chemical Substance Index,, 1977-1981, 95:133399v.
Chem. Abstracts, 11th Collective Chemical Substance Index, 1982-1986, 100:103930r.
Chem. Abstracts, 11th Collective Chemical Substance Index, 1982-1986, 100:103965f.
Chem. Abstracts, 11th Collective Chemical Substance Index, 1982-1986, 102:113990r.
Chem. Abstracts, 11th Collective Chemical Substance Index, 1982-1986, 104:19667a.
Chem. Abstracts, 11th Collective Chemical Substance Index, 1982-1986, 104:P 68890m.
Chem. Abstracts, 11th Collective Chemical Substance Index, 1982-1986, 105:227360c.
Chem. Abstracts, 11th Collective Chemical Substance Index, 1982-1986, 97:216812s.
Chem. Abstracts, 11th Collective Chemical Substance Index, 1982-1986, 99:23019w.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 106:138773t.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 106:214430w.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 107:7699w.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 108:P 169338a.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 109:7035t.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 110:213401h.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 110:76120z.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 110:95865n.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 112:235928d.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 113:132921n.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 113:98073a.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 114:101949u.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 114:144083z.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 114:62822a.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 114:P 62949x.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 115:159846v.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 115:208741t.
Chem. Abstracts, 12th Collective Chemical Substance Index, 1987-1991, 115:P 183368m.
Chem. Abstracts, 13th Collective Chemical Substance Index, 1992-1996, 116:152491n.
Chem. Abstracts, 13th Collective Chemical Substance Index, 1992-1996, 116:174924h.
Chem. Abstracts, 13th Collective Chemical Substance Index, 1992-1996, 116:60382z.
Chem. Abstracts, 13th Collective Chemical Substance Index, 1992-1996, 117:151437h.
Chem. Abstracts, 13th Collective Chemical Substance Index, 1992-1996, 117:192379j.
Chem. Abstracts, 13th Collective Chemical Substance Index, 1992-1996, 117:251937q.
Chem. Abstracts, 13th Collective Chemical Substance Index, 1992-1996, 117:27277s.
Chem. Abstracts, 13th Collective Chemical Substance Index, 1992-1996, 118:P263477y.
Chem. Abstracts, 13th Collective Chemical Substance Index, 1992-1996, 120:322653u.
Chem. Abstracts, 13th Collective Chemical Substance Index, 1992-1996, 123:prP313998v.
Chem. Abstracts, 13th Collective Chemical Substance Index, 1992-1996, 124:pr 318043k.
Chem. Abstracts, 8th Collective Chemical Substance Index, 1967, 70:115608s.
Chem. Abstracts, 8th Collective Chemical Substance Index, 1967, 70:77919j.
Chem. Abstracts, 8th Collective Chemical Substance Index, 1967, 72:P 66952e.
Chem. Abstracts, 8th Collective Chemical Substance Index, 1967, 73:66940v.
Chem. Abstracts, 8th Collective Chemical Substance Index, 1967, 74:13108u.
Chem. Abstracts, 8th Collective Chemical Substance Index, 1967, 75:151765c.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 76:60183r.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 76:99624k.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 76:P 85846x.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 77:P 5536d.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 78:154735r.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 78:42629c.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 78:85022a.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 78:P 136344h.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 78:P 159683g.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 79:105207g.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 79:53846t.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 79:53846t.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 79:53847u.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 79:P 115635j.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 80:82903k.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 81:106050d.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 81:64018s.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 81:P 136188x.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 81:P 82387r.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 82:156832b.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 82:170841k.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 82:98508n.
Chem. Abstracts, 9th Collective Chemical Substance Index, 1972-1976, 8
Heeres Jan
Janssen Paul A. J.
Kukla Michael Joseph
Ludovici Donald W.
Moereels Henri E. L.
Balasubramanian Venkataraman
Janssen Pharmaceutica Inc.
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