Substituted derivatives of 4-t-alkoxycarbonyl-piperazin-2-ones

Details Substituted derivatives of 4-t-alkoxycarbonyl-piperazin-2-ones Substituted derivatives of 4-t-alkoxycarbonyl-piperazin-2-ones

1982-07-19

1984-11-20

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

424250, 544229, 544374, 260239A, 2601125R, C07D24108

Patent

active

044839880

ABSTRACT:
Novel analgesic and antipsychotic agents having the formula ##STR1## in which R.sub.1 is hydrogen, hydroxy or halogen and R.sub.4 is hydrogen or, R.sub.1 and R.sub.4 are both hydroxy; Z is hydrogen or straight chain lower alkyl having from 1 to 4 carbon atoms and X is methylene, carbonyl, hydroxymethylene, thio, sulfinyl or sulfonyl, or Z and X, taken together, are methylidenyl, with the proviso that when X is sulfonyl or sulfinyl, Z is other than hydrogen; R.sub.5 is hydrogen or halogen, and R.sub.2 is H, a straight or branched lower alkyl group having from 1 to 4 carbon atoms, the group ##STR2## or the group ##STR3## wherein R.sub.3 is hydroxy, amino, alkylamino or dialkylamino wherein the alkyl moiety is straight or branched and has from 1 to 4 carbon atoms, diastereomers, enantiomers and pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 4079137 (1978-03-01), Cyrus et al.
patent: 4167512 (1979-09-01), Lai
patent: 4240961 (1980-12-01), Lai
Moureu et al., "Bull. Soc. Chim., France", 1956, pp. 1785-1787.
Saikawa et al., "Chemical Abstracts", vol. 89, 1976, col. 89:75453w.

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