Substituted cyclopentadienyl compounds for the treatment of infl

Details Substituted cyclopentadienyl compounds for the treatment of infl Substituted cyclopentadienyl compounds for the treatment of infl

1994-05-04

1995-05-23

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514344, 514345, 514709, 560102, 562492, 568 34, 568 33, 564 84, 549345, 549346, 549286, 549290, 549340, 549342, A61K 3118

Patent

active

054182549

ABSTRACT:
A class of 2,3-substituted cyclopenta-2,4-dienyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein each of R.sup.1 and R.sup.2 is independently selected from hydrido, lower alkyl, lower hydroxyalkyl, halo, lower haloalkyl, lower alkoxycarbonyl and carboxyl; and wherein each of R.sup.3 through R.sup.12 is independently selected from hydrido, halo, lower alkyl, lower alkylthio, cyano, hydroxyl, mercapto, lower haloalkyl, lower haloalkoxy, lower alkoxy, lower hydroxyalkyl, lower alkoxyalkyl, lower alkylsulfonyl, lower haloalkylsulfonyl and sulfamyl; provided R.sup.5 and R.sup.10 are not both hydrido or methoxy; or a pharmaceutically suitable salt or prodrug thereof.

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