Substituted cyclohexene derivatives as HMG-CoA reductase inhibit

Details Substituted cyclohexene derivatives as HMG-CoA reductase inhibit Substituted cyclohexene derivatives as HMG-CoA reductase inhibit

1990-11-27

1992-07-21

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549292, 558270, 558271, 558272, 560 9, 560 12, 560 13, 560 14, 560 27, 560 39, 560 31, 560 32, 562429, 562430, 562431, 562441, 562469, 546268, 546296, 546297, 546298, 546301, 546302, 546300, 546307, 546309, 546153, 546155, 546159, 546162, 514478, 514512, 514532, 514533, 514542, 514559, 514570, 514562, 514563, 514459, 514460, 514414, 514418, 514824, 514313, 514336, 514352, 514318, 514341, 514351, 514315, 548467, 548472, 548475, A61K 3117, A61K 31365, C07D21516, C07D30910

Patent

active

051323125

ABSTRACT:
Disclosed are novel 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof.
Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.

REFERENCES:
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patent: 4308378 (1981-12-01), Stokker
patent: 4503072 (1985-03-01), Hoffman et al.
patent: 4567289 (1986-01-01), Willard et al.
patent: 4611067 (1986-09-01), Volante et al.
patent: 4622338 (1986-11-01), Baran et al.
patent: 4668699 (1987-05-01), Hoffman et al.
patent: 4681893 (1987-07-01), Roth
patent: 4772629 (1988-09-01), Smith et al.

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