Substituted cyclohexanol esters, their use for treating diseases

Details Substituted cyclohexanol esters, their use for treating diseases Substituted cyclohexanol esters, their use for treating diseases

1996-12-11

1998-02-17

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546117, 546118, 546119, 546120, 544298, 514460, 514369, 514365, 514376, 514374, 514392, 514400, 514360, 514361, 514362, 514364, 514363, A61K 3142, A61K 31425, C07D41312, C07D41712

Patent

active

057191700

ABSTRACT:
Cyclohexanol esters of the formula I ##STR1## are described in which the radicals have the given meaning. The compounds are pharmacologically active and may therefore be used as pharmaceuticals, in particular for treating diabetes and other diseases which are characterized by an elevated secretion of glucose from the liver or by an elevated activity of the glucose-6-phosphatase system.

REFERENCES:
patent: 5463062 (1995-10-01), Hemmerle et al.
James Ashmore, et al., "The Role of Hepatic Glucose-6-phosphatase in the Regulation of Carbohydrate Metabolism", vol. XVII, 92-132 (1959).
Ann Burchell et al., "The Molecular Basis of the Hepatic Microsomal Glucose-6-phosphatase System", Biochem. Biophys. Acta 1092, 129-137 (1990).
James F. Soodsma et al., "The inhibition by Phlorizin of Kidney Microsomal Inorganic Pyrophosphata-Glucose Phosphotransferase and Glucose 6-Phosphatase", J. Biol. Chem. 242, 1955-1960 (1967).
Bruce K. Wallin et al., "The Requirement For Membrane Integrity In The Inhibition Of Hepatic Glucose 6-Phosphatase By Sulfhydryl Reagents And Taurocholate", Biochem. Biophys. Res. Commun. 48, 694-699 (1972).
Michael A. Zoccoli et al., "Effect of Two Inhibitors Of Anion Transport On The Hydrolysis Of Glucose 6-Phosphate By Rat Liver Microsomes", J. Biol. Chem. 255, 1113-1119 (1980).
Wesley K. Canfield et al., "The Glucose-6-phosphatase System In Rat Hepatic Microsomes Displays Hyperboli Kinetics At Physiological Glucose 6-phosphate Concentrations", J. Biol. Chem. 263, 7458-7460 (1988).
William J. Arion, "Measurement Of Intactness Of Rat Liver Endoplasmic Reticulum", Methods Enzymol., 174, Academic Press (1989) S. 58-67.
J.C Barriere et al., "Synthesis of Enantiomerically Pure Substituted Cyclopentenes From (-)-Quinic Acid", Helv. Chim. Acta 66, 269 (1983).

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