Substituted cyclohexane derivatives for the treatment of disease

Details Substituted cyclohexane derivatives for the treatment of disease Substituted cyclohexane derivatives for the treatment of disease

1993-09-07

1995-09-19

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 95, 514 99, 514143, 514148, 514277, 514357, 514399, 514438, 514445, 514519, 514506, 514866, 560 19, 560 20, 560 61, 560 62, 560 63, 560 76, 560104, 549 66, 549 79, 5483355, 5483415, 558 60, 558170, 558178, 558179, A61K 31675, A61K 31415, A61K 3138, A61K 31435

Patent

active

054515734

ABSTRACT:
Substituted cyclohexane derivatives for the treatment of diseases Esters of cyclohexane derivatives of the formula I ##STR1## in which A--B, R.sup.3, R.sup.4, R.sup.5, Y and Z have the meanings indicated, for use as inhibitors of the glucose-6-phosphatase system of the liver in mammals are described. The compounds are suitable for the production of pharmaceutical preparations.

REFERENCES:
S. E. Kahn et al., "The Pathophysiology of Type II (Noninsulin-Dependent) Diabetes Mellitus: Implications for Treatment," Diabetes Mellitus--Theory and Practice, 4TH Ed., Elsevier, N.Y., Chapter 26, pp. 436-456 (1990).
S. Efendic et al., "Mild Type II Diabetes Markedly Increases Glucose Cycling in the Postabsorptive State and during Glucose Infusion Irrespective of Obesity," J. Clin. Invest. 81, pp. 1953-1961 (Jun. 1988).
S. Ashcroft et al., "Effects of Phloretin and Dextran-Linked Phloretin On Pancreatic Islet Metabolism and Insulin Release," Biochimca Et Biophysica Acta, 538, pp. 334-342 (1978).
P. List et al., "Hagers Handbuch der Pharmazeutischen Praxis," 4. Ausgabe, Band 4, pp. 200-210; 415-418 (1973).
V. Litvinenko et al., "Gerbstoffe Und Oxyzimtsaureabkommlinge in Labiaten," Planta Medica, Band 27, pp. 372-380 (1975).
S. Juchi et al., "Anti-allergic foods containing caffeic and/or caffetannie acid," Chemical Abstracts, Band 104, Nr. 17, 28, p. 573 (1986).
H. Taguchi et al., "Pharmaceuticals for treatment of influenza virus infection," Chemical Abstracts, Band 104, Nr. 14, 7, p. 402 (1986).
"Chlorogensaure in Semen Coffeae und ihre Veranderung beim Rostproze.beta.*", R. Krasemann, Archiv Der Pharmazie 293/65(8):721-733 (1960).
"Isolation And Structural Elucidation Of A New Lipoxygenase Inhibitor From Gardeniae Fructus", Nishizawa et al., Chem. Pharm. Bull. 34(3):1419-1421 (1986).

Affiliated with

Also associated with

Rating

Substituted cyclohexane derivatives for the treatment of disease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted cyclohexane derivatives for the treatment of disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted cyclohexane derivatives for the treatment of disease will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1828228