Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-10-11
2005-10-11
Aulakh, Charanjit S. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S232000, C546S197000, C548S566000, C564S090000, C514S428000, C514S608000
Reexamination Certificate
active
06953806
ABSTRACT:
The present invention provides compounds of formula (I)wherein A1, A2, A3, A4, A5, A6, A7, A8, A9, A10, U, V, W, m, n and p are as indicated in the specification, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia and hyperlipemia.
REFERENCES:
patent: 5455273 (1995-10-01), Maier et al.
patent: 5495048 (1996-02-01), Aebi et al.
patent: 6034275 (2000-03-01), Aebi et al.
patent: 6140354 (2000-10-01), Dax et al.
patent: 6211241 (2001-04-01), Islam et al.
patent: 0 599 203 (1994-06-01), None
patent: 0 636 367 (1995-02-01), None
Gotto et al., Circulation 81, 1990, pp. 1721-1733.
Stein, et al., Nutr. Metab. Cardiovasc. Dis. 2, 1992, pp. 113-156.
Illingworth, Med. Clin. North. Am. 84, 2000, pp. 23-42.
Ross et al., Arch. Intern. Med. 159, 1999, pp. 1793-1802.
Ellen & McPherson, J. Cardiol. 81, 1998, pp. 60B-65B.
Shepherd, Eur. Heart J. 16, 1995, pp. 5-13.
Davignon et al., Can. J. Cardiol. 8, 1992, pp. 843-864.
Pederson & Tobert, Drug Safety 14, 1996, pp. 11-24.
Morand et al., J. Lipid Res., 38, 1997, pp. 373-390.
Mark et al., J. Lipid Res. 37, 1996, pp. 148-158.
Peffley et al., Biochem. Pharmacol. 56, 1998, pp. 439-449.
Nelson et al., J. Biol. Chem. 256, 1981, pp. 1067-1068.
Spencer et al., J. Biol. Chem. 260, 1985, pp. 13391-13394.
Panini et al., J. Lipid Res. 27, 1986, pp. 1190-1204.
Ness et al., Arch. Biochem. Biophys. 308, 1994, pp. 420-425.
Janowski et al., Proc. Natl. Acad. Sci. USA, 96, 1999, pp. 266-271.
Venkateswaran et al., J. Biol. Chem. 275, 2000, pp. 14700-14707.
Schmitz & Kaminsky, Front Biosci 6, 2001, pp. D505-D514.
Ordovas, Nutr Rev 58, 2000, pp. 76-79.
Tobin et al., Mol. Endocrinol. 14, 2000, pp. 741-751.
Costet, P. et al, The Journal of Biological Chemistry, vol. 275, No. 36, Sep. 18, 2000, pp. 28240-28245.
Wang, N. et al., The Journal of Biological Chemistry, vol. 275, No. 42, Oct. 20, 2000, pp. 33053-33058.
H. Rueeger, et al., Bioorganic and Medicinal Chemistry Letters, vol. 10, No. 11, pp. 1175-1179 (2000).
Ackermann Jean
Aebi Johannes
Dehmlow Henrietta
Hirth Georges
Maerki Hans-Peter
Aulakh Charanjit S.
Hoffmann-La Roche Inc.
Johnston George W.
Megerditchian Samuel H.
Tramaloni Dennis P.
LandOfFree
Substituted cyclohexane derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted cyclohexane derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted cyclohexane derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3464588