Substituted cycloalkyl lactamimides

Details Substituted cycloalkyl lactamimides Substituted cycloalkyl lactamimides

1978-02-14

1978-11-21

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

546284, 546304, 546312, 546223, 546213, 260239BE, 2603265L, 424244, 424267, 424274, C07D20722, C07D21172, C07D22312, C07D22502

Patent

active

041266129

ABSTRACT:
Compounds possessing hypoglycemic, hypotensive, anti-inflammatory, anticoagulant and diuretic activity are represented by compounds of the following formula ##STR1## wherein Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.

REFERENCES:
patent: 3887569 (1975-06-01), Poos

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