Substituted cycloalkanecarboxylic acid derivatives as matrix met

Details Substituted cycloalkanecarboxylic acid derivatives as matrix met Substituted cycloalkanecarboxylic acid derivatives as matrix met

1997-05-30

1999-03-23

Lambkin, Deborah C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514621, 514619, 514618, 514568, 514561, 514545, 514539, 548539, 564169, 564163, 564162, 562460, 562440, 562426, 560 52, 560 42, A61K 3140, A61K 31165, C07D20700, C07C23300

Patent

active

058860223

ABSTRACT:
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T is a substituent g roup; x is 0, 1, or 2; the group D represents ##STR2## the subscript "e" is 2 or 3; the group R.sup.14 represents a variety of possible substituent groups of the cycloalkyl ring between D and G; the subscript "k" is 0-2; and the group G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12 ; and R.sup.13 represents any of the side chains of the 19 noncyclic occurring amino acids.

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