Substituted cyclic tetrapeptides

Details Substituted cyclic tetrapeptides Substituted cyclic tetrapeptides

1991-05-21

1993-06-01

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530330, 514 11, 514 18, A61K 3700, A61K 3702, C07K 500, C07K 700

Patent

active

052161242

ABSTRACT:
The present invention provides substituted cyclic tetrapeptide compounds of Formula I: ##STR1## and the pharmaceutically acceptable salts, esters and amides thereof, which are useful for treating pain in animals, pharmaceutical compositions which comprises a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

REFERENCES:
patent: 4518711 (1985-05-01), Hruby et al.
patent: 4760180 (1988-07-01), Pitzele et al.
Mosberg et al., Life Sciences, vol. 43, pp. 1013-1020, Aug. 5, 1988.
Bradbury, et al., i Nature, 260, 793 (1976).
Belluzzi, et al., Nature, 260, 625 (1976).
Kiso, et al., "Peptide Chemistry 1981", Protein Research Foundation, Osaka, Japan, 65-70 (1982).
Vavrek, et al., Peptides, 2, 303 (1981).
Mosberg, et al., Proc. Natl. Acad. Sci. USA, vol. 80, pp. 5871-5874, Oct. 1983.

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