Substituted cyclic pentapeptides

Details Substituted cyclic pentapeptides Substituted cyclic pentapeptides

1991-05-21

1992-12-08

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514114J, 514809, 530302, 530330, 930 80, A61K 3700, C07K 500

Patent

active

051698331

ABSTRACT:
The present invention provides substituted cyclic pentapeptide compounds of general Formula I: ##STR1## and the pharmaceutically-acceptable slats, esters and amides thereof, which are useful for inducing analgesia in animals, pharmaceutical compositions comprising a pharmaceutically-acceptable carrier and a compound of Formula I, and a method for inducing analgesia in an animal in need thereof comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

REFERENCES:
patent: 4371463 (1983-02-01), Pert et al.
patent: 4495178 (1985-01-01), Hanser, Jr. et al.
patent: 4518711 (1985-05-01), Hruby et al.
patent: 4760180 (1988-07-01), Pitzele et al.
Mosberg, et al., Life Sciences, 43 1013-1020 (1988).
Bradbury, et al., Nature, 260, 793 (1976).
Belluzzi, et al., Nature, 260, 625 (1976).
Kiso, et al., "Peptide Chemistry 1981," Protein Research Foundation, Osaka, Japan, 65-70 (1982).
Vavrek, et al., Peptides, 2, 303 (1981).
Mosberg, et al., Proc. Natl. Acad. Sci. USA, vol. 80, pp. 5871-5874, Oct. 1983.

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