Cleaning compositions for solid surfaces – auxiliary compositions – Cleaning compositions or processes of preparing – For cleaning a specific substrate or removing a specific...
Patent
1993-10-08
1995-04-04
Cintins, Marianne M.
Cleaning compositions for solid surfaces, auxiliary compositions
Cleaning compositions or processes of preparing
For cleaning a specific substrate or removing a specific...
560 10, 560 15, 560 18, 560 24, 560 25, 560 26, 560 34, 560 51, 560 53, 560 54, 560 55, 560 56, 560 60, 560 76, 560 80, 560100, 562433, 562439, 562459, 562461, 562470, 562473, 562488, 562490, C07K 7100
Patent
active
054039525
ABSTRACT:
Novel substituted cyclic compounds of Formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis, tumor invasion in certain cancers, periodontal disease, corneal ulceration, proteinuria, dystrophic epidermolysis bullosa, and coronary thrombosis associated with atherosclerotic plaque rupture. The matrix metalloendoproteinases are a family of zinc-containing proteinases including but not limited to stromelysin, collagenase, and gelatinase, that are capable of degrading the major components of articular cartilage and basement membranes. The inhibitors claimed herein may also be useful in preventing the pathological sequelae following a traumatic injury that could lead to a permanent disability. These compounds may also be useful as novel birth control agents by preventing ovulation or implantation. ##STR1##
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Caldwell Charles G.
Gooley Paul R.
Hagmann William
Cintins Marianne M.
MacMillan Keith
Merck & Co. , Inc.
North Robert J.
Panzer Curtis C.
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