Substituted cyanamide compounds useful for the manufacture of ce

Details Substituted cyanamide compounds useful for the manufacture of ce Substituted cyanamide compounds useful for the manufacture of ce

1984-11-29

1987-10-20

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

560251, 549367, 549374, 549451, C07C12508

Patent

active

047015560

ABSTRACT:
The invention relates to a process for the manufacture of a cephalosporin derivative of the formula I: ##STR1## in which X is a sulphur or oxygen atom or a sulphinyl radical, R.sup.1 is any one of the C-3 substituents from antibacterially-active cephalosporins known in the art, R.sup.2 is a hydrogen atom or a 1-6C alkyl or 2-6C alkenyl radical, R.sup.3 is a hydrogen atom or one of a variety of radicals defined in the specification, and the pharmaceutically-acceptable acid- and base-addition salts thereof, characterized by reaction of a compound of the formula IX: ##STR2## in which R.sup.16 and R.sup.17 individually have one of the values given above for R.sup.2 and R.sup.3, or a derivative thereof in which the carbonyl group is masked, with a compound of the formula X: ##STR3## in which R.sup.18 is a hydrogen atom or any one of the cephalosporin 3-carboxylic acid protecting groups known in the art; whereafter, when R.sup.18 is other than a hydrogen atom, the protecting group R.sup.18 is replaced by hydrogen by conventional means.

REFERENCES:
patent: 2331671 (1943-10-01), Ericks
patent: 2370663 (1945-03-01), Hill
patent: 2727068 (1955-12-01), Benneville
patent: 3849465 (1974-11-01), Marsh
patent: 4358447 (1982-11-01), Hannah
J. Chem. Soc. 1956, 307-310.
J. Amer. Chem. Soc. 1955, 77, 1056.

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