Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-03-21
2006-03-21
Seaman, D. Margaret (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C546S157000, C546S167000, C546S283100, C514S312000, C514S291000, C514S307000, C514S314000, C514S422000, C514S444000, C514S456000, C548S517000, C549S315000, C549S013000, C549S399000
Reexamination Certificate
active
07015328
ABSTRACT:
The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I:wherein A, B, X, Y, and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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Cai Sui Xiong
Drewe John
Jiang Songchun
Kemnitzer William E.
Storer Richard
Cytovia, Inc.
Seaman D. Margaret
Shire BioChem Inc.
Sterne Kessler Goldstein & Fox P.L.L.C.
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