Substituted cinnoline derivatives as CNS depressants

Details Substituted cinnoline derivatives as CNS depressants Substituted cinnoline derivatives as CNS depressants

1986-05-29

1989-12-12

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514248, 544116, 544119, 544235, 548469, 558391, 558445, 564215, 564305, 564442, A61K 31535, A61K 3150, C07D41312, C07D23728

Patent

active

048868000

ABSTRACT:
The present invention comprises certain amide and ester derivatives of 4-substituted-cinnoline-3-carboxylic acids and 3-acyl-4-substituted-cinnoline derivatives, and their use as central nervous system (CNS) depressants.

REFERENCES:
patent: 3657241 (1972-04-01), Kurihara
patent: 4027023 (1977-05-01), Preston et al.
patent: 4085103 (1978-04-01), Preston et al.
patent: 4379929 (1983-04-01), Conrad et al.
patent: 4729782 (1988-03-01), Labovitz et al.
patent: 4826837 (1989-05-01), Doria et al.
The Condensed Chemical Dictionary, (10th Ed.), Van Nostrand Reinhold Co., Publishers, p. 19 (1981).
Hackh's Chemical Dictionary, (4th Ed.), McGraw-Hill Book Co., Publishers, p. 16 (1972).
Patel, J. B. and Malick, J. B., "Effects of Isoproterenol and Chlordiazepoxide on Drinking and Conflict Behaviors in Rats", Pharmacology Biochemistry & Behavior (1980), 12: 819-821.
Meiners, B. A. and Salama, A. I., "Enhancement of Benzodiazepine and Gaba Binding By the Novel Anxiolytic, Tracazolate", Eur. Journal of Pharmacology (1982), 78: 315-322.
Braestrup, Claus and Squires, Richard F., "Specific benzodiazepine receptors in rat brain characterized by high-affinity [.sup.3 H]diazepam binding", Proceedings of the National Academy of Science U.S.A. (1977) 74: 3805.
Wastek, G. J., Speth, R. C., Reisine, T. D. and Yamamura, H. I., "The Effect of gamma-aminobutyric Acid on .sup.3 H-Flunitrazepam Binding in Rat Brain", Eur. Journal of Pharmacology (1978) 50: 445.
Bylund, D. B., Receptor Binding Techniques, Society for Neuroscience (1980), vol. 6, p. 1.
Gassman, Paul G. and Gruetzmacher, Gordon D., "Azasulfonium Salts. Intermediates in a General Procedure for the Alkylation of Aromatic Amines", J. Amer. Chem. Soc., (1974) 96: 5487-5495.
Sikkar, Rein and Martinson, Per, "Synthesis and Dediazoniation of 2-Butyl- and 2,5-Dibutylbenzenediazonium Ions", Acta Chemica Scandinavica (1980) B34:551-557.
Chorvat, Robert J., Desai, Bipin N., Radak, Suzanne Evans, McLaughlin, Kathleen T., Miller, James E., Jett, Charlene and Rohrbacher, Elaine, "22-Hydroxycholesterol Derivatives as HMG CoA Reductase Suppressors and Serum Cholesterol Lowering Agents", Journal of Medicinal Chemistry (1985) 28: 194-200).
Hayashi, T., et al., J. Amer. Chem. Soc. (1984) 106: 158.
Gerlach, H. et al., Helv. Chim. Acta. (1977) 60, Fasc. 8: 2860-2865.
Chemical Abstracts, vol. 87 (1977), p. 603, No. 117893f.
Chemical Abstracts, vol. 82, No. 139453m, (1975).

Affiliated with

Also associated with

Rating

Substituted cinnoline derivatives as CNS depressants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted cinnoline derivatives as CNS depressants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted cinnoline derivatives as CNS depressants will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2121819