Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as

Details Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as

1985-08-12

1987-08-11

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514522, 514525, 514533, 514544, 514546, 514568, 514685, 514708, 514710, 514701, 514713, 514720, 514733, 514456, 514469, 558413, 558414, 558415, 558416, 558423, 560 11, 560 18, 560 53, 560 59, 560 65, 560 66, 560 67, 560138, 560141, 562429, 562432, 562463, 562469, 562473, 562475, 568 31, 568 33, 568 37, 568 43, 568 47, 568 49, 568 52, 568337, 568442, 568637, 568638, 568645, 568646, 568744, 568745, 549405, 549408, 549462, C07C 3921, A61K 3105

Patent

active

046862358

ABSTRACT:
Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophlic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.

REFERENCES:
patent: 3745222 (1973-07-01), Jurd et al.
patent: 3865748 (1975-02-01), Jurd et al.
patent: 4105698 (1978-08-01), Starks
Baggaley et al, Jour. Chem. Soc., D1970 (1) 6-7.

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