Substituted chromone-3-carbonitriles, carboxamides and carboxyli

Details Substituted chromone-3-carbonitriles, carboxamides and carboxyli Substituted chromone-3-carbonitriles, carboxamides and carboxyli

1974-09-09

1976-02-10

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Lipid or oil

A61K 3135

Patent

active

039378373

ABSTRACT:
Substituted chromone-3-carbonitriles, carboxamides and carboxylic acids having the structural formula: ##SPC1##
Wherein R.sub.1 represents hydrogen, halogen, lower alkyl, hydroxy, lower alkoxy, or acyloxy; R.sub.2 represents hydrogen, lower alkyl, fluorinated lower alkyl, alkoxycarbonyl, carboxy, or lower alkyl carboxylic acid; Z represents cyano, carboxy, alkoxycarbonyl, or ##EQU1## wherein X represents amino, N-lower-alkylamino, hydroxylamino, N-lower-alkylhydroxylamino, ureido, piperidino, or anilino, with the proviso that when R.sub.2 represents hydrogen, Z represents cyano or ##EQU2## wherein X has the same meaning as given above; and wherein R.sub.2 and Z together may form a substituted pyrrole ring; and the corresponding non-toxic, pharmaceutically acceptable salts.

REFERENCES:
patent: 3692796 (1972-09-01), Freedman

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