Substituted chroman derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C544S376000, C544S359000, C540S553000

Reexamination Certificate

active

07056921

ABSTRACT:
The present invention relates to new new piperidyl- or piperazinyl-substituted dihydro-2H-1-benzopyran derivatives compound having the formula (I)whereinX is N or CH;Y is NR2CH2, CH2NR2, NR2CO, CONR2, NR2SO2or NR2CONR2wherein R2is H or C1–C6alkyl;R1is H, C1–C6alkyl or C3–C6cycloalkyl;R3is C1–C6alkyl, C3–C6cycloalkyl or (CH2)n-aryl,wherein aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted with R4and/or R5;and n is 0–4;as (R)-enantiomers, (S)-enantiomers or a racemate in the form of a free base or a pharmaceutically acceptable salt or solvate thereof, a process for their preparation, pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds.

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patent: 6479497 (2002-11-01), Berg et al.
patent: 9012795 (1990-11-01), None
patent: 9109853 (1991-07-01), None
patent: 9707120 (1997-02-01), None

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