Substituted cephene-4-carboxylates and their method of preparati

Details Substituted cephene-4-carboxylates and their method of preparati Substituted cephene-4-carboxylates and their method of preparati

1973-01-02

1976-06-08

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50106, C07D50122, C07D50129

Patent

active

039622231

ABSTRACT:
Novel desacetoxycephalosporin derivatives of the formula ##EQU1## in racemic or optically active form or cis and trans forms and mixtures thereof wherein R is selected from the group consisting of aminophenyl and R', R' is selected from the group consisting of phenyl optionally substituted with at least one member of the group consisting of halogen and nitro and a 5 to 6 member heterocyclic group, Y is selected from the group consisting of amino, NHCOOR" where R" is alkyl of 1 to 5 carbon atoms, hydrogen and hydroxy, A is selected from the group consisting of alkyl of 2 to 5 carbon atoms and cycloalkyl of 3 to 7 carbon atoms optionally containing a heteroatom and R.sub.1 is selected from the group consisting of hydrogen, easily acid hydrolyzable group and easily hydrogenolysis removable group, with the proviso that when R is aminophenyl Y is other than amino and NHCOOR" and R.sub.1 is hydrogen and when Y is amino, R.sub.1 is hydrogen and the non-toxic pharmaceutically acceptable addition salts of with organic and inorganic bases and acids where appropriate which have antibacterial activity and a novel process for their preparation and novel intermediates therefor.

REFERENCES:
patent: 3634417 (1972-01-01), Attenburrow
patent: 3655656 (1972-04-01), Van Heyman, Jr.
patent: 3769280 (1973-10-01), Parker
patent: 3828037 (1974-08-01), De Marinis et a.

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