Substituted carbamoyl and oxycarbonyl derivatives of biphenylmet

Details Substituted carbamoyl and oxycarbonyl derivatives of biphenylmet Substituted carbamoyl and oxycarbonyl derivatives of biphenylmet

1992-07-17

1994-05-17

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142305, 5142348, 514297, 514312, 514313, 514346, 514349, 514381, 514394, 514418, 514419, 514450, 514471, 514596, 514597, 514598, 544 52, 544105, 544354, 544355, 544356, 549401, 549483, 549484, 549487, 546102, 546103, 546104, 546105, 546106, 546153, 546159, 546163, 546168, 546169, 546292, 548251, 5483064, 5483074, 5483615, 5483621, 548483, 560 27, 564 48, 564 49, 564 50, 564 51, 564 52, A61K 3147, A61K 31415, A61K 3134, A61K 31535, A61K 3154, A61K 3117, A61K 3127, C07C27528, C07D20716, C07D26536, C07D27504,

Patent

active

053128206

ABSTRACT:
Carbamoyl and oxycarbonyl derivatives of biphenylmethylamines of structure I are angiotensin-II antagonists with balanced AT.sub.1 and AT.sub.2 activity useful in the treatment of hypertension and related disorders and ocular hypertension. ##STR1## where X is --O-- or --N(R.sup.7)--.

REFERENCES:
patent: 3910911 (1975-10-01), Ishizumi et al.
patent: 4410697 (1983-10-01), Torok et al.
patent: 4422871 (1983-12-01), Schirmer et al.
patent: 5157040 (1992-10-01), Greenlee et al.

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