Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai
Reexamination Certificate
2007-04-03
2007-04-03
Witherspoon, Sikarl A. (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ketone doai
C514S732000, C568S375000, C568S377000
Reexamination Certificate
active
10496593
ABSTRACT:
The invention relates to the use of substituted bicyclo[3.3.1]nonan-2,4,9-triones, especially clusianon and clusianon derivatives, as pharmaceutical active ingredients or medicamentous active ingredients, especially for producing medicaments for the prophylactic and/or therapeutic (curative) treatment of tumour or cancer diseases, and of viral diseases. The above-mentioned compounds can be used in cytostatic agents and antiviral agents (virostatic agents). They are especially used as inhibitors of topoisomerases and telomerases and as regulators during the MAP kinase signal transduction and can thus intervene on a cellular scale in the mechanism for multiplication of tumour or cancer cells and viruses.
REFERENCES:
Porto et al. Polyisoprenylated benzophenones from Clusia floral resins. Phytochemistry. 55, 2000, p. 755-768.
Oliveira et al. Floral Resins of Clusia SPP.: Chemical Composition and Biological Function.□□Tetraheron Letters, vol. 37 (36), 1996, p. 6427-6430.
Henry et al. Prenylated Benzophenone Derivatives from Carribean Clusia species (Guttiferae).□□Tetrahedron, vol. 55, 1999, p. 1581-1596.
Diaz-Carballo David
Hilger Ralf Axel
Seeber Siegfried
Bachman & LaPointe P.C.
Diagenics International Corporation
Witherspoon Sikarl A.
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