Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-09-25
2007-09-25
Anderson, Rebecca (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S443000, C546S114000, C549S050000
Reexamination Certificate
active
10527762
ABSTRACT:
The present invention addresses substituted thiophene derivatives, as well as compositions containing such compounds and methods of treatment. The compounds in the present invention are glucagon antagonists. The compounds block the action of glucagon at its receptor and thereby decrease the levels of plasma glucose providing a treatment of diabetes.
REFERENCES:
Fujita et al. “Synthesis and Bioactivities of Novel Bicylic Thiophenes and 4,5,6,7-Tetrahydrothieno[2,3-c]pyridines as Inhibitors of Tumor Necrosis Factor-a (TNF-a) Production” Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, pp. 1897-1900.
Fujita, et al—Database Cas Online on STN, Chem. Abstra., Accession No. 2002:510557, 2002.
Fujita, M. et al., “Snthesis and Bioactivities of Novel Bicylic Thiophenes and 4,5,6,7-Tetrahydrothienol[2,3-c]pyridines as Inhibitors of Tumor Necrosis Factor-alpha (TNF-alpha) Production” Bioorganic & Medicinal Chemistry Letters, vol. 12, pp. 1897-1900, 2002.
Campbell Elizabeth Louise
Duffy Joseph
Konteatis Zenon
Liang Rui
Anderson Rebecca
Billups Richard C.
Fitch Catherine D.
Kosack Joseph R.
Merck & Co. , Inc.
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