Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-08-13
2010-02-16
Balasubramanian, Venkataraman (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S326000, C544S328000, C544S330000, C544S331000, C544S194000, C514S246000
Reexamination Certificate
active
07662830
ABSTRACT:
Substituted biaryl piperazinyl-pyridine analogues are provided, of the Formula:wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptors activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
REFERENCES:
patent: 4260621 (1981-04-01), Roch et al.
patent: 4824846 (1989-04-01), Kampe et al.
patent: 5589477 (1996-12-01), Chokai et al.
patent: 5962453 (1999-10-01), Ueda et al.
patent: 6414149 (2002-07-01), Chu-Moyer et al.
patent: 6417185 (2002-07-01), Goff et al.
patent: 6660740 (2003-12-01), Chu-Moyer et al.
patent: 6710058 (2004-03-01), Jacobson et al.
patent: 6894047 (2005-05-01), Mylari
patent: 2002/0132807 (2002-09-01), Wang et al.
patent: 2003/0060466 (2003-03-01), Binggeli et al.
patent: 2007/0027155 (2007-02-01), Bakthavatchalam et al.
patent: 2007/0043049 (2007-02-01), Bakthavatchalam et al.
patent: 2007/0161637 (2007-07-01), Bakthavatchalam et al.
patent: 2008/0045525 (2008-02-01), Bakthavatchalam et al.
patent: 0459830 (1991-12-01), None
patent: 0 775 487 (1997-05-01), None
patent: 1 136 483 (2001-09-01), None
patent: 1 136 483 (2001-09-01), None
patent: 1 247 809 (2002-10-01), None
patent: 2 262 512 (1975-09-01), None
patent: 49 021148 (1974-05-01), None
patent: WO-98/24782 (1998-06-01), None
patent: WO-00/09496 (2000-02-01), None
patent: WO-01/70728 (2001-09-01), None
patent: WO-02/02539 (2002-01-01), None
patent: WO-02/08221 (2002-01-01), None
patent: WO-04/000820 (2003-12-01), None
patent: WO-2004/048365 (2004-06-01), None
patent: WO-2005/007648 (2005-01-01), None
Johansen, M.E. et al., “TRPV1 Antagonists Elevate Cell Surface Populations of Receptor Protein and Exacerbate TRPV1-Mediated Toxicities in Human Lung Epithelial Cells”,Toxicological Sciences89(1), 278-286 (2006) (Advance Access publication Aug. 24, 2005).
Thomas, Karen C. et al., “Transient Receptor Potential Vanilloid 1 Agonists Cause Endoplasmic Reticulum Stress and Cell Death in Human Lung Cells,”The Journal of Pharmacology and Experimental Therapeutics321(3), 830-838 (2007).
Bolcskei, Kata et al., “Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice,”Pain117, 368-376 (2005).
Helyes, Zsuzsanna et al., “Role of transient receptor potential vanilloid 1 receptors in endotoxin-induced airway inflammation in the mouse,”Am J Physiol Lung Cell Mol Physiol. 292(5):L1173-81 (2007).
Banvolgyi, Agnes et al., “Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model,”J Neuroimmunol. 169, 86-96 (2005).
U.S. Appl. No. 11/795,651, filed Jul. 19, 2007, Charles Blum.
Luo et al., “Microwave-assisted synthesis of aminopyrimidines,” Tetrahedron Letters 43:5739-5742 (2002).
Ojea et al., “Synthesis of Pyrazino[1,2-a:4,5-a']D1[1,8]Naphthyridine and Pyrazino[1,2-a][1,8]Naphthyridines,” Heterocycles 36:1337-1349 (1993).
Ram et al., “Synthesis of Pyrimidines and Fused Pyrimidines as Leishmanicides,” Journal fuer Praktische Chemie 331:957-963 (1989).
Agarwal et al., “A diversity oriented synthesis of highly functionalized unsymmetrical biaryls through carbanion induced ring transformation of 2H-oyran-2-ones,” Tetrahedron 58:8793-8798 (2002).
Ram et al., “One-pot synthesis of unsymmetrical biaryls from suitably functionalized 2H-pyran-2-ones through carbanion-induced ring-transformation reactions,” J. Chem. Soc. Perkin Trans. 16:1953-1959 (2001).
Chu-Moyer et al., “Orally-Effective, Long-Acting Sorbitol Dehydrogenase Inhibitors: Synthesis, Structure-Activity Relationships, and in Vivo Evaluations of Novel Heterocycle-Substituted Piperazino-Pyrimidines,” J. Med. Chem. 45:511-528 (2002).
Xia et al., “Substituted 1,3,5-Triazines as Cholesteryl Ester Transfer Protein Inhibitors,” Bioorganic & Medical Chemistry Letters 6:919-922 (1996).
Farhanullah et al., “Synthesis of Aminonicotinonitriles and Diaminopyridines through Base-Catalyzed Ring Transformation of 2H-Pyran-2-ones,” J. Org. Chem. 68:2983-2985 (2003).
Ram et al., “Synthesis of *-Deficient Pyrimidines as Leishmanicides,” Arch. Pharm. 324:837-839 (1991).
Vishwakarma et al., “Reactions of Polarized Keten S,N-Acetals with Guanidine: A Facile General Route to Novel 5,6-Substituted 2-Amino-4-N-alkyl/aryl/N-azacycloalkylaminopyrimidines,” Indian Journal of Chemistry 24B:466-471 (1985).
SciFinder Report for CAS Registry No. 477866-20-9, Apr. 30, 2003.
SciFinder Report for CAS Registry No. 380546-69-0, Apr. 29, 2003.
SciFinder Report for CAS Registry No. 339279-02-6, Apr. 30, 2003.
SciFinder Report for CAS Registry No. 477866-17-4, Jan. 1, 2004.
SciFinder Report for CAS Registry No. 667895-91-2, Jul. 7, 2004.
SciFinder Report for CAS Registry No. 477863-89-1, Jan. 1, 2004.
SciFinder Report for CAS Registry No. 552286-80-3, Apr. 30, 2003.
SciFinder Report for CAS Registry No. 330981-81-2, Apr. 30, 2003.
Wang et al., “Amino-substituted heterocycles as isosteres oftrans-cinnamides: design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding”, Bioorganic & Medicinal Chemistry Letters 15 (2005) pp. 195-201.
The Extended European Search Report dated Apr. 6, 2009, from corresponding EPO application No. 05810146.0.
Blum Charles A.
Brielmann Harry
Chenard Bertrand L.
Zheng Xiaozhang
Balasubramanian Venkataraman
Corless Peter F.
Edwards Angell Palmer & & Dodge LLP
Neurogen Corporation
Russett Mark D.
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