Substituted benzyloxycarbonylguanidines, a process for their pre

Details Substituted benzyloxycarbonylguanidines, a process for their pre Substituted benzyloxycarbonylguanidines, a process for their pre

1996-05-15

1998-05-19

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564237, 564 85, 514311, 514357, 514603, 546152, 546332, A61K 31155, C07C27910

Patent

active

057537100

ABSTRACT:
Substituted benzyloxycarbonylguanidines, a process for their preparation, their use as a medicament or diagnostic, and a medicament containing them. There are described compounds of the formula I ##STR1## in which the substituents R(1) to R(7) and X have the meanings shown in the claims, and their pharmaceutically tolerable salts. These are effective inhibitors of the cellular sodium proton antiporter (Na.sup.+ /H.sup.+ exchanger). They are therefore outstandingly suitable for the treatment of all diseases which can be attributed to increased Na.sup.+ /H.sup.+ exchange.

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Rempp Chemie Lexikori: pp. 579 and 391.
See the Search Report, Examples 5 Abstract.
Scholz, W. et al.: Hoe 694, a new Na.sup.+ /H.sup.+ exchange inhibitor and its effects in cardiac Ischaemia Br. J. Pharmacol. 109:582-568, 1993.
Derwent Abstract of EP 0 612 723.
Derwent Abstract of EP 0 416 489.
Derwent Abstract of EP 0 640 588.
Derwent Abstract of BE 844 832.

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