Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1998-01-09
2000-02-08
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
564 56, 564230, 546139, 546152, 546333, 514307, 514311, 514357, A61K 3117, C07C27504
Patent
active
060228997
ABSTRACT:
There are described compounds of the formula I ##STR1## in which the substituents R(1) to R(7) and X have the meanings shown in the claims, and their pharmaceutically tolerable salts. These are effective inhibitors of the cellular sodium proton antiporter (Na.sup.+ /H.sup.+ exchanger). They are therefore outstandingly suitable for the treatment of all diseases which can be attributed to increased Na.sup.+ /H.sup.+ exchange.
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patent: 5292755 (1994-03-01), Englert et al.
Krug, et al., "Pochodne Guanidyny. II*, Nowe Metody Otrzymywania Niektorych Acylopochodnych Guanidyny," Roczniki Chemii. vol. 41, pp. 1087-1091, 1967.
Rompp Chemie Lexikon, pp. 579 and 391.
Albus Udo
Brendel Joachim
Kleemann Heinz-Werner
Lang Hans-Jochen
Scholz Wolfgang
Aulakh Charanjit S.
Hoechst Aktiengesellschaft
Kight John
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